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Vitamin B12 is a member of the vitamin B complex. It also called cobalamin and is important to good health. There are two types of commercial vitamin B12: cyanocobalamin and methylcobalamin. New Roots Herbal uses only the methyl form, as it is the coenzyme form and the only type which can directly participate in homocysteine metabolism. In addition, converting homocysteine to methionine via methylcobalamin generates an increased supply of S‑adenosylmethionine (SAMe), the body’s most important methyl donor. Indeed, some of the benefits of methylcobalamin, such as protection from neurotoxicity, appear to derive from increased production of SAMe. It helps maintain healthy nerve cells and red blood cells, and is also needed to make DNA, the genetic material in all cells. Vitamin B12 is bound to protein in food; hydrochloric acid in the stomach releases vitamin B12 from protein during digestion. Once released, vitamin B12 combines with a substance called intrinsic factor (IF) before it is absorbed into the bloodstream.
Vitamin B12 is also necessary for the rapid synthesis of DNA during cell division. This is especially important in tissues where cells are dividing rapidly, particularly bone marrow tissues responsible for red blood-cell formation. If a deficiency occurs, DNA production is disrupted and abnormal cells, called megaloblasts, are formed; this results in anemia. Symptoms include excessive tiredness, breathlessness, listlessness, pallor, and poor resistance to infection. Other symptoms can include a smooth, sore tongue and menstrual disorders. Anemia may also be due to folic acid deficiency, folic acid also being necessary for DNA synthesis.
When deficiency occurs, it is more commonly linked to a failure to effectively absorb vitamin B12 from the intestine rather than a dietary deficiency. Absorption of vitamin B12 requires the secretion from the cells lining the stomach of a glycoprotein, known as intrinsic factor. The vitamin B12 intrinsic factor complex is then absorbed in the ileum (part of the small intestine) in the presence of calcium. Certain people are unable to produce intrinsic factor, and the subsequent pernicious anemia is treated with injections of vitamin B12.
Adults: Take 1 capsule daily with food or as directed by your health-care practitioner.
Duration of use: Consult a health-care practitioner for prolonged use.
Contains no: Eggs, citrus, preservatives, artificial flavour or colour, starch, or sugar.
Cautions and warnings: Consult a health-care practitioner prior to use if you have diabetes or galactosemia; if you have allergy to latex or fruits (such as avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, and tomato); if you have gastrointestinal lesions/ulcers; if you are taking anti-inflammatory agents or other enzyme products; or if you are having surgery. Discontinue use and consult a health-care practitioner if symptoms persist or worsen. Discontinue use if you develop symptoms of liver trouble (such as abdominal pain, dark urine, or jaundice). Do not use if you have liver or gall bladder disorders, bowel obstruction, or if you are taking anticoagulants or blood thinners.
Contraindications: Do not use if you are pregnant or breast-feeding; or after recent surgery.
Known adverse reactions: Headaches, heartburn, bloating, hypersensitivity (e.g. allergy), nausea, vomiting, and diarrhea have been known to occur; in which case, discontinue use. May cause bloating, cramping, and constipation.
Do not use if seal is broken. Keep out of reach of children.
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